In a Assessment, Mitchell Lee and colleagues try to separate reality from fiction for so-called “anti-aging” dietary interventions. In addition they discover these diets’ potential shared mechanisms of motion. For nearly a century, caloric restriction and different dietary interventions have been recognized to increase life span and delay age-associated illness – no less than in laboratory animals – however simply how these interventions work stays unclear.
What’s extra, regardless of the current popularization of a few of these diets, corresponding to ketogenic diets and intermittent fasting, the efficacy and security of those diets for people has but to be established exterior of a laboratory setting. Right here, Lee et al. summarize the present literature regarding probably the most studied anti-aging dietary interventions – those who seem to delay or reverse the hallmark molecular mechanisms of getting older. Whereas these interventions are effectively studied in mannequin organisms, like mice, flies and yeast, it isn’t at present doable to know whether or not comparable diets have an effect on organic getting older in individuals, in line with the authors.
Analysis so far reveals that the physiological penalties of those dietary interventions are advanced, even within the easiest mannequin organisms; it has additionally revealed intriguing similarities throughout anti-aging diets. In accordance with Lee et al., a standard mechanism for anti-aging diets could also be associated to the inhibition of the protein kinase mTOR. This evolutionarily conserved signaling pathway could present a molecular goal for medicine that might show helpful for growing well being longevity in people.
“Future analysis ought to deal with each higher understanding the mobile and molecular mediators of anti-aging diets below extremely managed laboratory circumstances in addition to the impression of genetic and environmental variation on well being outcomes related to these diets,” write Lee et al.
Supply:
Journal reference:
Lee, M.B., et al. (2021) Anti-aging diets: Separating reality from fiction. Science. doi.org/10.1126/science.abe7365.