New ingredients are elbowing their way into the joint health market

The joint well being substances market is seeing a flurry of latest exercise as demand for a brand new technology of merchandise leads formulators to eschew legacy substances like glucosamine and chondroitin in favor of rising substances like collagen and turmeric. To realize validation, these next-generation joint well being substances are specializing in strong medical trials and formulation.

The Collagen Craze

Collagen dietary supplements not too long ago made the leap from the sweetness aisle to the joint well being aisle based mostly on research displaying it could relieve joint ache. Analysis on the interactions between the varied sorts of collagen is now opening up new alternatives for synergistic, mixture joint well being dietary supplements mixing complementary substances in a single product.

One 2021 medical trial¹ examined the results of Fortigel, a branded bioactive collagen peptide by Gelita (Eberbach, Germany), on knee ache in 180 bodily energetic adults aged 18 to 30 with activity-related joint ache and scores above 20 on the Visible Analog Scale (VAS) for ache. The topics got the McMurray check for meniscus harm, the Steinmann I and II assessments, and the Butler drawer check to evaluate ligament stability at baseline and on examine conclusion. Topics obtained both 5 g of Fortigel (n = 98), or a placebo (n =82), each day for 12 weeks. After 12 weeks, the group receiving collagen peptides skilled an enchancment in activity-related joint ache as assessed on the VAS, by the doctor, and thru self-report. The examine authors concluded collagen peptides can scale back knee ache throughout exercise.

Angie Rimel, advertising and marketing communications supervisor for Gelita, says collagen is turning into well-liked in multi-ingredient merchandise particularly. “Collagen could be very straightforward to formulate with,” Rimel says. “There’s a rising development of mix merchandise, like protein blends or with nutritional vitamins or prebiotics.”

Abdul Alkayali, vp of Licensed Nutraceuticals Inc. (Temecula, CA), says a few of the most enjoyable innovation in collagen has to do with a brand new supply: jellyfish. In actual fact, Alkayali expects invertebrates to switch mammals as the first supply of collagen within the coming years.

“Jellyfish collagen provides the physique with a number of sorts of collagen peptides and important minerals which can be solely present in edible jellyfish collagen,” Alkayali says. “New analysis on jellyfish has elevated tremendously.”

A 2017 60-day potential single-center observational examine² assessed Licensed Nutraceuticals’ branded TendoGuard, a joint well being mix together with Varieties I, II, V, and X collagen, in addition to hyaluronic acid, chondroitin sulfate, and mucopolysaccharides. This examine examined the results of a 750 mg/day dose of TendoGuard on joint ache and vary of movement in 20 women and men aged 45 to 75 with a historical past of a knee dysfunction. Topics have been assessed for vary of movement through goniometer, ache through the Borg scale, and muscle power through a sphygmomanometer. After 60 days, the topics noticed enhancements in vary of movement, ache, and muscle power. Whereas this examine lacked a management group, the examine authors concluded that TendoGuard lowered signs of joint discomfort.

Research like these are driving gross sales of collagen merchandise within the joint well being market. Douglas Jones, world gross sales and advertising and marketing supervisor for Biocell Expertise LLC (Irvine, CA), says shoppers are on the lookout for clinically validated substances that present noticeable advantages. He expects the joint well being market to current alternatives for collagen manufacturers which have medical analysis behind them.

“Biocell has seen our collagen gross sales improve with some prospects by over 100% inside the final 18 months,” Jones says. “We see shoppers on the lookout for at-home options to take care of their joint well being. The long run in joint well being could be very brilliant. Millennials at the moment are of their 30s, and this inhabitants could be very targeted on supply-side transparency and branded substances with medical proof.”

Whereas Millennials characterize a rising alternative for future progress, most joint well being shoppers are nonetheless older adults. A 2021 shopper survey by Lonza (Basel, Switzerland) discovered that the typical joint well being shopper is between the ages of 45 and 64. Based on Lonza’s analysis, joint well being complement shoppers are typically properly educated and have excessive incomes. Lindsey Toth, RD, affiliate director of well being substances for Lonza, says that with one in six folks projected to be 65 years outdated or older by 2050, now’s the time to start laying the groundwork of shopper schooling campaigns.

“Whereas collagen has taken middle stage lately, there may be largely little recognized by shoppers in regards to the several types of collagens and the distinction in advantages they confer,” Toth says. “Lonza has invested important analysis in understanding the advantages of undenatured sort II collagen.”

Lonza’s branded UC-II collagen, an undenatured sort II collagen ingredient, has been discovered to extend mobility and scale back joint discomfort in medical research, Toth says. One of many benefits of one of these collagen, Toth notes, is comfort of supply. “UC-II collagen will be taken in a tiny, once-daily, easy-to-swallow dose. Capsule fatigue and swallowability issues are an enormous barrier for many growing older shoppers.”

Whereas collagen is an efficient ingredient for joint well being, not all sorts of collagen are created equal. Jaume Reguant, healthcare director for Bioiberica (Barcelona, Spain), says formulators who need to work with collagen might want to think about which sort of collagen is greatest for his or her utility.

“Native sort II collagen is an efficient joint well being ingredient and in comparison with its hydrolyzed counterpart requires a a lot decrease dosage,” Reguant says. “This implies it may be integrated alongside different useful substances to help joint well being.”

“Rising substances like this are facilitating a brand new period of mobility well being that appeals to a wider vary of people that see motion as a basic a part of their bodily and psychological well-being,” he provides.

One latest animal examine³ examined the efficacy of mixing Bioiberica’s branded Collavant n2 ingredient (previously known as 2Cool), which is an undenatured sort II collagen, and Mobilee, which is a hyaluronic acid matrix ingredient, in a system that additionally included Bioiberica’s chondroitin sulfate and glucosamine hydrochloride substances. The examine assessed the mix’s results on articular cartilage, synovial membrane, and subchondral bone in 54 rabbits with induced osteoarthritis. The rabbits have been randomly assigned to obtain a each day dose of both 1) chondroitin sulfate (CS) plus glucosamine hydrochloride (GH) and hyaluronic acid (HA) (n=18), 2) CS plus GH and HA with added Collavant n2 (n=18), or 3) nothing (n=18). Every group was divided into three subgroups (n=6) that have been sacrificed after 28, 56, or 84 days. After sacrifice, the rabbits have been dissected and evaluated. The rabbits that obtained the mix of CS, GH, and HA confirmed milder degenerative adjustments relative to the management group. The addition of Collavant strengthened this protecting impact, the researchers concluded.

Different new analysis on collagen is demonstrating the viability of a customized vitamin strategy. Liz Clarke, CFS, technical advertising and marketing supervisor for Nitta Gelatin (Morrisville, NC), says new analysis on joint well being substances goes past offering scientific substantiation of well being advantages for the final inhabitants. As a substitute, research at the moment are zeroing in on medical personalization for particular demographics like youthful athletes or seniors with mobility points.

One latest randomized, double-blind, placebo-controlled medical trial⁴ on Nitta Gelatin’s branded Wellnex Replenwell collagen peptide examined the results of collagen supplementation on joint ache in wholesome male college college students aged 18 to 21 who have been members of the Josai College working membership in Sakado, Japan. The scholars have been randomly assigned to obtain both 5 g of Replenwell per day (n = 25) or a maltodextrin placebo (n = 21), for eight weeks. After 4 weeks, the placebo group noticed a rise in ranges of interleukin-6 (IL-6), a biomarker of irritation. The collagen peptide group didn’t see any important adjustments in IL-6 ranges. The examine discovered {that a} each day dose of Replenwell taken for 4 weeks lowered joint discomfort.

“Personalization is the important thing right here,” Clarke says. “We’re seeing important outcomes with decrease dosage charges for energetic, youthful contributors than we have now in earlier research trying on the results on older populations with preexisting joint circumstances. Whereas it’s commonsense that completely different populations would have differing wants, with the ability to quantify that into dosage necessities is new for collagen.”

Turmeric Beneficial properties Floor

One relative newcomer to the joint well being market is beginning to shake issues up and threaten the dominance of legacy substances. Latest analysis is displaying that turmeric (Curcuma longa) can scale back joint irritation in additional methods than one.

Eric Anderson, managing director of NXT USA (Metuchen, NJ), says the corporate’s branded TamaFlex, a patent-pending mix of Tamarindus indica seed and turmeric rhizome extracts, is proving to be efficient in addressing joint well being points like consolation, flexibility, and performance. One 2019 randomized, double-blind, placebo-controlled examine⁵ examined the results of TamaFlex in 90 non-arthritic topics with knee ache and joint discomfort. Topics have been randomized to obtain both 250 mg (n=30) or 400 mg (n=30) of TamaFlex per day, or a placebo (n=29), for 90 days. Topics have been assessed through the Six-Minute Stroll Take a look at and Stair Climb Take a look at at baseline and after 90 days. Each TamaFlex teams noticed a rise in common strolling pace and enhancements on Six-Minute Stroll Take a look at and Stair Climb Take a look at scores in comparison with placebo, in addition to reductions in ache and stiffness.

“The newest examine on TamaFlex confirmed that it begins working in 5 days,” Anderson says. “This examine, pending publication, explored how TamaFlex impacted topics with delicate to reasonable joint ache from osteoarthritis. It confirmed enhancements in ache, stiffness, bodily exercise, and stair climbing scores by day 5.”

Different research are demonstrating that turmeric may also be an efficient joint well being ingredient when integrated into polyphenol blends. A latest open-label feasibility trial⁶ on Verdure Sciences’ (Noblesville, IN) branded curcumin/polyphenol mix Restoridyn examined the results of the mix on blood inflammatory proteins and inflammation-associated RNA in 18 half-marathon runners for 29 days earlier than, the day of, and the day after a race.

The contributors obtained 1 g/day of Restoridyn for the primary 26 days and a pair of g/day on days 27 by way of 31. The topics have been additionally permitted to take a further 1 g/day booster dose on days 1 by way of 26, however solely on days after they ran greater than 6 miles. Topics have been assessed for irritation and soreness through testing for IL-10, IL-13, IL-4, TNF-alpha, and RNA biomarkers, amongst a number of others, on days 29 by way of 31.

The examine discovered that Restoridyn altered a number of pathways related to irritation, B-cell exercise, and muscle restoration. Restoridyn downregulated a kind of lengthy, non-coding RNA that’s recognized to be concerned in irritation and COX-2 expression.

Kristen Marshall, digital advertising and marketing supervisor at Verdure Sciences, says the joint well being market is starting to diversify into extra subcategories and specialised functions. Joint well being manufacturers are increasing into a number of practical arenas like train restoration and sports activities vitamin, joint consolation, ache and stiffness, irritation, and total wholesome way of life.

“Joint well being has developed to incorporate an ever-increasing array of functions, features, and codecs,” Marshall says. “We’re seeing many manufacturers diversify their product choices with revolutionary supply types like topicals, goodies, practical drinks, and extra.”

Analysis on different types of turmeric is ongoing, and a few of these research present that an unconventional sort of turmeric extract might provide substantial benefits. Brien Quirk, director of analysis and growth for Draco Pure Merchandise (San Jose, CA), says a water-soluble polysaccharide extract sourced from turmeric rhizomes was discovered to be very efficient at relieving signs of osteoarthritis in a medical trial⁷.

This examine—a randomized, single-blind, placebo-controlled trial—examined the results of NR-INF-02, a branded powdered curcumin rhizome product marketed as Turmacin by Pure Cures Pvt. Ltd. (Bangalore, India), on ache and knee operate in 120 topics with knee osteoarthritis. Individuals have been randomly assigned to obtain both 1) 400 mg of a placebo twice per day (n=30), or 2) 500 mg of Turmacin twice per day (n=30), 3) 750 mg of glucosamine sulfate twice per day (n=30), or 4) a mix of glucosamine sulfate and Turmacin twice per day (n=30), for 42 days. The topics have been assessed for ache through the VAS and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scales, and joint situation through the Scientific International Impression Change (CGIC) scale, at baseline and after 21 and 42 days.

After 42 days, the topics who obtained Turmacin confirmed a big enchancment in VAS, WOMAC, and CGIC scores and a big lower in the usage of ache remedy relative to placebo. The examine authors concluded that Turmacin is a protected and efficient choice for relieving ache and enhancing knee operate in osteoarthritis sufferers.

“Many of the turmeric extracts being offered in the marketplace are standardized to a focus of 95% curcumin and don’t have water-soluble polysaccharides,” Quirk says. “Curcumin could be very poorly absorbed, which explains why most turmeric extracts haven’t proven a lot profit besides in very giant doses. Turmeric extracts which can be wealthy in water-soluble polysaccharides have been ignored till now.”

Eggshell Membrane Powerhouse

Eggshell membrane substances are gaining recognition in joint well being functions for his or her wealthy mixture of joint-healthy compounds. Amanda Jepson, senior director of promoting and worldwide gross sales for Biova LLC (Johnston, IA), says eggshell membrane is a supply of a number of, naturally occurring compounds that promote joint well being. These embody substances like collagen, elastin, glucosamine, chondroitin, and several other amino acids.

One 2019 examine⁸ on Biova’s branded BiovaFlex water-soluble egg membrane ingredient demonstrated strong outcomes. The 12-week randomized, double-blind, placebo-controlled medical trial examined the results of a 450-mg each day dose of BiovaFlex (n = 44) on WOMAC scores and efficiency on the Six-Minute Stroll Take a look at relative to placebo (n = 44).

“The worst-performing topics within the BiovaFlex group at baseline had essentially the most important enchancment inside 5 days,” Jepson says. “The BiovaFlex group additionally famous a discount in joint stiffness inside 5 days.”

New technique of measuring the efficacy of substances are additionally lending momentum to the joint well being area. Jacqueline Rizo, content material coordinator for Stratum Diet (Carthage, MO), says that whereas joint well being substances have sometimes been evaluated utilizing ache and stiffness scales, latest improvements have made it doable to measure ingredient efficacy by way of goal biomarkers like CTX-II, the C-terminal telopeptide fragments of sort II collagen.

“One of many important developments associated to NEM”—the corporate’s flagship eggshell membrane ingredient—“in latest months was the publication of analysis concerned within the growth of a medical trial design for evaluating the results of joint therapeutics on cartilage turnover,” Rizo says. “This medical trial marked the primary proof suggesting CTX-II may very well be used to guage the chondroprotective efficacy of joint therapeutics in wholesome people.”

The trial⁹ in query, sponsored by Stratum Diet’s mum or dad firm ESM Applied sciences (Carthage, MO), adopted 60 wholesome, postmenopausal girls for 14 days. The ladies obtained both 500 mg of NEM per day (n=30), or a placebo (n=30), whereas doing step workouts (50-100 steps per leg) on alternating days. NEM administration resulted in sooner restoration from exercise-induced joint ache and stiffness, in addition to lowered discomfort, relative to placebo.

MSM—A Versatile Possibility

Whereas the joint well being advantages of methylsulfonylmethane (MSM) have been established for a while, latest medical trials inspecting MSM together with different joint well being substances have discovered that MSM has a synergistic impact.

Tim Hammond, vp of gross sales and advertising and marketing for Bergstrom Diet (Vancouver, WA), says Bergstrom’s branded OptiMSM is right for brand spanking new merchandise due to its relative affordability, robust security profile, and confirmed efficacy.

“In depth analysis has proven that MSM decreases joint ache, improves stiffness and swelling, and will increase the vary of movement and bodily operate of people with osteoarthritis,” Hammond says. “OptiMSM’s possible mechanism stems from its skill to lower pro-inflammatory cytokines, scale back oxidative injury, and provide a wealthy supply of sulfur.”

One 2017 randomized, double-blind, placebo-controlled trial¹⁰ examined the efficiency of a glucosamine-chondroitin sulfate product each with and with out MSM in relieving signs of osteoarthritis. The topics, all of whom had both grade I or grade II osteoarthritis in response to the Kellgren-Lawrence scale, obtained both 1) 1,500 mg of glucosamine and 1,200 mg of chondroitin sulfate (n=49), or 2) 1,500 mg of glucosamine, 1,200 mg of chondroitin sulfate, and 500 mg of MSM (n=50), or 3) an identical placebo (n=48) each day for 3 months. The topics have been assessed for joint ache on the WOMAC and VAS scales at baseline and after 4, 8, and 12 weeks. By the tip of the examine, the group that obtained the mix of glucosamine, chondroitin sulfate, and MSM exhibited essentially the most important enhancements in WOMAC and VAS scores.

Botanicals

Numerous botanicals are displaying promise as joint well being dietary supplements in medical trials. A number of of those merchandise might current appreciable benefits over legacy substances. Steve Fink, vp of promoting for PLT Well being Options (Morristown, NJ), says botanical substances like Boswellia serrata take impact sooner and require a decrease dosage than a few of the established substances available in the market.

“If we take a look at essentially the most generally used pure options for mobility help, two issues stand out: they require comparatively giant doses, they usually require a very long time to point out efficacy,” Fink says.

In distinction, Fink says Boswellia extracts and different botanicals have been discovered to take impact in as little as 5 days and to be efficient with doses as little as 100 mg. PLT’s branded Boswellia serrata, Dynagenix Muscle+Joint Method, is a low-dose joint well being ingredient that may be formulated in RTD merchandise, powders, and extra. One 2019 randomized, double-blind, placebo-controlled medical trial examined the results of Dynagenix Muscle+Joint Method in 50 wholesome, energetic males aged 25 to 40. On this unpublished examine, topics obtained 60 mg of Boswellia serrata per day (n=25), or an identical placebo (n=25), for 10 days. Topics underwent an eccentric train routine, which includes muscle tissue contracting and lengthening in fast succession, on day 7. The topics have been assessed for muscle and joint soreness through the VAS, knee vary of movement, total stiffness, and biomarkers of irritation like IL-6 and cytokines at baseline and as soon as each day on days 7 by way of 10. The topics who obtained Boswellia serrata skilled a discount in joint soreness and a sooner restoration of knee vary of movement relative to the management group.

One other wealthy supply of rising joint well being botanicals is the world of conventional Chinese language medication. David Liu, PhD, is the chief expertise officer for Chenland Nutritionals (Irvine, CA). Liu says the status of sure joint well being substances in conventional folks medication programs like conventional Chinese language medication and Ayurveda is prompting researchers to take a better take a look at these substances.

“With the event and utilization of omics and bioinformatics in these analysis fields, the scientific implication of natural formulation has been elucidated, which has led to a greater understanding of and acceptance by the western science neighborhood,” Liu explains. “Herbs like Dioscorea nipponica, Andrographis paniculata, and Acacia catechu have been clinically studied for his or her efficacies in relieving joint discomfort associated to knee osteoarthritis.”

Chenland not too long ago accomplished a six-month, open-label human medical trial on its JointAlive ingredient, which comprises extracts of Epimedium brevicornum Maxim, Dioscorea nipponica Makino, and Salvia miltiorrhiza Bunge. Liu says that on this yet-to-be-published trial, JointAlive was 85% efficient at decreasing WOMAC scores. He says this trial additionally discovered that JointAlive begins to alleviate joint discomfort in as little as two days.

Chenland can be actively pursuing a randomized, double-blind, placebo-controlled medical trial¹¹ on JointAlive in partnership with KGK Science (London, ON, Canada). This examine, which is at present recruiting contributors, will study the efficacy of JointAlive in assuaging joint ache and enhancing knee operate in an in any other case wholesome inhabitants with delicate to reasonable knee osteoarthritis. Liu says the final topic will probably be enrolled in September 2021, and a ultimate report on the medical trial is predicted by the tip of this yr.

Formulators are additionally trying towards botanical substances which can be fairly well-known for functions in meals. Steve Holtby, president and CEO of Mushy Gel Applied sciences Inc. (Los Angeles, CA), says one rising joint well being ingredient is healthier recognized for its function in making beer.

“Hops, the ingredient used so as to add a contact of bitterness to most brews, has been studied due to its joint well being properties,” Holtby explains. Mushy Gel Applied sciences’ Perluxan softgels, derived from hops (Humulus lupulus) “comprise a singular botanical anti-inflammatory agent that has been clinically demonstrated to shortly relieve minor joint ache.”

Mushy Gel Applied sciences solely markets Perluxan as a resin. Pharmachem Laboratories (Kearny, NJ), a division of Ashland (Wilmington, DE) that has carried out intensive analysis¹² on Perluxan, owns the trademark for Perluxan as a powder.

One randomized, double-blind, parallel-design trial¹³ on 19 topics pitted Perluxan towards ibuprofen. The topics have been randomly assigned to obtain both 1) 400 mg of ibuprofen as soon as per day, 2) a softgel containing 450 mg of the hops resin as soon as per day, or 3) a 300-mg capsule containing a powdered type of the hops resin 4 occasions per day, for 14 days. Each hops formulations inhibited COX-2 in addition to ibuprofen beginning 9 hours after the preliminary dose; nonetheless, the hops formulations didn’t inhibit COX-1, whereas ibuprofen did.

“It was fascinating to notice that the hops resin softgel was solely administered as soon as over a nine-hour interval however was as efficient as ibuprofen,” Holtby says. “The Perluxan softgel had a sooner onset of motion and progressively lowered pain-causing enzymes over the interval of the examine.”

Different botanical blends are additionally displaying promise in joint well being. Indena’s (Milan, Italy) branded Mitidol, a mix of ginger (Zingiber officinale) and paracress (Acmella oleracea), underwent a pilot examine that was printed in 2020. This examine¹⁴, a single-group pretest-posttest quasi-experimental trial, examined the results of Mitidol on ache, irritation, and knee operate in 50 topics aged 40 to 75 with knee osteoarthritis. All topics obtained two 350-mg tablets of Mitidol each day for 4 weeks (n=50); there was no placebo group. The topics have been assessed for WOMAC and Tegner Lysholm Knee Scoring Scale scores at baseline and after 15 and 30 days. They have been additionally evaluated for ache on the Visible Analogue Scale, high quality of life through the 36-Merchandise Quick-Kind Well being Survey, and biomarkers of irritation through C-reactive protein and erythrocyte sedimentation fee testing at baseline and after 30 days.

The topics noticed a big lower in VAS scores within the left and proper knees after 10 and 11 days, respectively. WOMAC scores additionally decreased all through the examine, from a gaggle common of 44 to 38. The group’s common Lysholm rating elevated from 65 at baseline to 73 after 30 days, indicating an enchancment in knee operate.

Whereas a number of of the research on botanicals for joint well being have targeted on growing older older adults, this market is starting to see curiosity from youthful shoppers—and Annie Eng, CEO of HP Substances (Bradenton, FL), says the following technology of joint well being complement customers is already on the lookout for clinically validated preventative upkeep merchandise.

“The joint help market continues on a quick monitor of growth because the Millennial technology, who’re very energetic and health-conscious, start to be proactive about joint care,” Eng says. “To make sure they and like-minded older adults have entry to merchandise that work to protect joint construction and promote joint operate, we’re launching a brand new human medical trial.”

This new examine, led by Juan Hancke, PhD, is a randomized, double-blind, placebo-controlled medical trial. The examine will study the results of each day consumption of HP Substances’ branded Andrographis paniculata product, ParActin, on knee operate in knee osteoarthritis sufferers. The examine will observe the topics for one yr. Earlier this yr, ParActin obtained a pure product license from Well being Canada.¹⁵

Thrilling Occasions Forward

The joint well being area is seeing important disruption and innovation. Rising substances are gaining momentum as medical trials show their efficacy, carving out a spot available in the market subsequent to extra established rivals. Because the joint well being market continues to develop, merchandise like turmeric, botanicals, and collagen will achieve additional traction. As this area grows extra aggressive, success in joint well being will rely on convincing shoppers that your ingredient stands on a robust basis of science.

Sidebar: Hyaluronic Acid Normalizes Synovial Fluid

Michael Grenner, gross sales supervisor of meals and vitamin uncooked supplies, North America, at Bloomage Biotechnology USA (Hawthorne, NJ), says pure, non-GMO, and natural substances are rising within the joint-health area.

Grenner says hyaluronic acid is displaying up in joint well being formulations together with MSM, chondroitin, and different substances. Bloomage’s Haplex Plus comprises sodium hyaluronate, the salt type of hyaluronic acid (HA). Research have proven that HA can normalize synovial fluid¹⁶, relieve joint ache¹⁷, and defend cartilage from denaturation¹⁸.

Sidebar: Pea Reduces Joint Ache

One latest examine¹⁹opened the door for a brand new joint-health contender. A 2021 randomized, double-blind, placebo-controlled trial discovered {that a} 350-mg each day dose of Gencor’s (Irvine, CA) Levagen, a branded palmitoylethanolamide (PEA) ingredient, lowered Visible Analogue Scale scores for joint ache in wholesome adults aged 25 to 70. Whereas the placebo group (n = 39) additionally noticed a discount in scores, that discount lasted solely 10 days earlier than scores started to rise once more, whereas the PEA group’s (n = 35) scores decreased over your complete course of the examine.

“PEA demonstrated within the examine its anti-inflammatory and analgesic properties, together with its skill to affect the endocannabinoid system,” says Maggie McNamara, advertising and marketing director for Gencor. “PEA downregulates a number of pro-inflammatory and nociceptive pathways and is understood to inhibit glial cell exercise.”

Sidebar: New Type of Chondroitin Improves Knee Operate in OA Sufferers

Whereas chondroitin sulfate has an extended historical past of use in joint well being, issues round sourcing are resulting in improvements on this ingredient. Xavier Berger, advertising and marketing supervisor for mobility and joint well being at Gnosis by Lesaffre (Lille, France), says shopper issues round animal welfare and cross-contamination have prompted formulators to supply chondroitin from crops. Gnosis’s branded chondroitin product Mythocondro is one instance of this development.

“Mythocondro helps scale back the danger of osteoarthritis and joint degeneration,” Berger says. “Further advantages embody ache reduction, anti-inflammatory exercise, and elevated articular operate.”

One latest medical trial²⁰ on Mythocondro discovered {that a} 600 mg/day dose lowered irritation, WOMAC scores, and C-reactive protein ranges in overweight adults with reasonable knee osteoarthritis after eight weeks.

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