Printed in Medical Diet, researchers from the College of Minnesota Medical Faculty checked out colonic hydrogen sulfide — a poisonous fuel within the physique that smells like rotten eggs — manufacturing in individuals in response to animal- and plant-based eating regimen interventions.
“Though the position of hydrogen sulfide has lengthy been a topic of nice curiosity within the pathogenesis of a number of essential ailments — reminiscent of ulcerative colitis, colon most cancers, and weight problems — previous investigations haven’t been capable of hyperlink dietary knowledge, microbiome characterization and precise hydrogen sulfide manufacturing,” mentioned Alexander Khoruts, MD, a gastroenterologist within the U of M Medical Faculty and M Well being Fairview. “That is what now we have completed right here.”
From a human cohort, the examine helps the overall speculation that hydrogen sulfide produced by the intestine microbiota will increase with an animal-based eating regimen. Nonetheless, the outcomes additionally recommended the existence of intestine microbiome enterotypes that reply differentially and even paradoxically to completely different dietary enter.
The examine discovered that:
- Within the majority of members, a plant-based eating regimen resulted in a decrease hydrogen sulfide manufacturing in comparison with an animal-based (i.e., western) eating regimen.
- As anticipated, a plant-based eating regimen contained extra fiber, whereas an animal-based eating regimen contained extra protein.
- In some people, plant-based diets didn’t decrease hydrogen sulfide manufacturing and even led to some will increase in it.
- Preliminary outcomes recommended the existence of various compositions of intestine microbiota (enterotypes) that correlate with differential responsiveness to eating regimen by way of hydrogen sulfide manufacturing.
“The examine was per the overall understanding that common consumption of fiber-containing meals is helpful to intestine well being,” mentioned Dr. Levi Teigen, a vitamin researcher within the Division of Gastroenterology within the U of M Medical Faculty. “Future analyses of the intestine microbiome might assist to individualize vitamin interventions.”
The examine was funded by Wholesome Meals Wholesome Lives, Reaching Cures Collectively, the Allen Basis and the College of Minnesota MnDRIVE Initiative. The analysis crew envisions future work that may result in extra personalised dietary counseling that will likely be knowledgeable by microbiome-based diagnostics.
Story Supply:
Materials offered by University of Minnesota Medical School. Unique written by Kat Dodge. Notice: Content material could also be edited for type and size.
