What Is Cinqair?
Cinqair (reslizumab) is a prescription treatment used to deal with adults with extreme eosinophilic asthma—a sort of bronchial asthma that creates excessive ranges of eosinophils. Eosinophils are a sort of white blood cell and are a part of your physique’s immune response. If eosinophil ranges develop into too excessive, irritation can happen and worsen your bronchial asthma signs.
Cinqair belongs to a gaggle of medicine known as monoclonal antibodies. It really works by reducing eosinophil ranges, which may also help scale back bronchial asthma assaults and enhance your respiration.
Cinqair is an intravenous (IV) answer and should be administered intravenously (into your vein with a needle) by a healthcare supplier.
Drug Info
Generic Title: Reslizumab
Model Title: Cinqair
Drug Availability: Prescription
Therapeutic Classification: IL-5 inhibitor, monoclonal antibody
Obtainable Generically: No
Managed Substance: No
Administration Route: Intravenous
Energetic Ingredient: Reslizumab
Dosage Kind: Intravenous answer
What Is Cinqair Used For?
The Meals and Drug Administration (FDA) has authorised Cinqair to deal with adults with extreme eosinophilic asthma who haven’t responded to different remedies. When added to your common bronchial asthma remedy, Cinqair may also help forestall extreme bronchial asthma assaults and enhance your respiration.
Cinqair is often mixed with different bronchial asthma medicines for upkeep remedy. It isn’t a rescue treatment and won’t deal with an energetic bronchial asthma assault. Speak together with your healthcare supplier about what it is best to do if you happen to develop an bronchial asthma assault.
Find out how to Take Cinqair
Cinqair is an intravenous (IV) treatment that your healthcare supplier administers into your vein as an infusion each 4 weeks. Every infusion usually takes 20–50 minutes. After receiving Cinqair, your healthcare supplier will monitor you for any indicators of an allergic response earlier than going house.
How Lengthy Does Cinqair Take to Work?
Cinqair helps scale back bronchial asthma assaults and enhance your respiration over time. It could take as much as 4 months of remedy to see the complete results.
What Are the Aspect Results of Cinqair?
This isn’t an entire record of unwanted effects and others might happen. A healthcare supplier can advise you on unwanted effects. In case you expertise different results, contact your pharmacist or a healthcare supplier. Chances are you’ll report unwanted effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.
Frequent Aspect Results
Cinqair is mostly well-tolerated, and most of the people do not expertise any unwanted effects. The commonest unwanted effects embody throat ache and muscle ache. Let your healthcare supplier know if you happen to develop any unwanted effects that hassle you or do not go away.
Extreme Aspect Results
Hardly ever, Cinqair might trigger severe and typically life-threatening reactions. Name your healthcare supplier immediately if you happen to develop any extreme unwanted effects. Name 911 in case your signs really feel life-threatening.
Severe unwanted effects and their signs embody:
A extreme allergic response known as anaphylaxis. These reactions can result in loss of life. Your healthcare supplier will monitor you throughout your Cinqair infusion and after remedy. Let your healthcare supplier know if you happen to develop any indicators of an allergic response, together with:
- Bother respiration
- Flushing, itching, or hives
- Fainting
- Dizziness or lightheadedness
- Confusion
- Quick heartbeat
- Paleness
- Nausea or vomiting
- Swelling of your face, lips, mouth, or tongue
Irregular cell development that could be cancerous.
Report Aspect Results
Cinqair might trigger different unwanted effects. Name your healthcare supplier when you have any uncommon issues whereas taking this treatment.
In case you expertise a severe aspect impact, you or your supplier might ship a report back to the FDA’s MedWatch Adverse Event Reporting Program or by cellphone (800-332-1088).
Dosage: How A lot Cinqair Ought to I Take?
Your dose of Cinqair will usually be primarily based in your weight. Your healthcare supplier will calculate an acceptable dose for you. Cinqair is run as an IV infusion (into your vein utilizing a needle) by your healthcare supplier as soon as each 4 weeks.
Modifications
Being pregnant: It isn’t recognized if Cinqair can hurt a fetus. Let your healthcare supplier know if you’re pregnant or plan to develop into pregnant earlier than beginning Cinqair.
Lactation: It isn’t recognized if Cinqair passes into breastmilk or what impact it might have on a child. Speak together with your healthcare supplier about one of the simplest ways to feed your child.
Youngsters: Cinqair is just authorised to deal with adults with extreme eosinophil bronchial asthma. The security and effectiveness of utilizing Cinqair in youngsters haven’t been studied.
Adults over 65 years: Based mostly on outcomes from scientific trials, Cinqair seems to be simply as protected and efficient in older adults in comparison with youthful adults.
Precautions
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Your physician will test your progress carefully when you are receiving this medication. This may enable your physician to see if the drugs is working correctly and to determine if you happen to ought to proceed to obtain it and to test for negative effects.
This medication might trigger severe allergic reactions, together with anaphylaxis. Anaphylaxis may be life-threatening and requires quick medical consideration. Inform your physician immediately when you have a rash, itching, lightheadedness, dizziness, or fainting, bother respiration, bother swallowing, or any swelling of your palms, face, or mouth when you are utilizing this medication.
Hold utilizing your corticosteroid medication to manage your bronchial asthma, along with this medication. This contains steroid medicines which can be taken by mouth or inhaled (together with cortisone, fluticasone, prednisone).
Utilizing this medication might enhance your danger of getting pores and skin most cancers. Speak to your physician when you have issues about this danger.
You will need to inform your physician that you’re pregnant when you are receiving this medication.
What Are Causes I Should not Take Cinqair
Sure circumstances enhance your danger of creating issues from Cinqair. Don’t take Cinqair if you happen to:
- Are allergic to reslizumab or some other ingredient in Cinqair.
- Have a present helminth (parasitic worm) an infection. You must obtain remedy on your an infection earlier than beginning Cinqair.
What Different Drugs Work together With Cinqair?
Most medicines do not work together with Cinqair. Nonetheless, it is necessary to maintain an up-to-date record of all of the medicines, dietary supplements, and natural preparations that you simply take and let your healthcare supplier and pharmacist know any time there are adjustments.
What Drugs Are Comparable?
Cinqair belongs to a gaggle of medicines known as monoclonal antibodies and works by reducing eosinophil ranges. Eosinophils are a sort of immune cell that often assist defend your physique towards infections. However when eosinophil ranges develop into too excessive, irritation can happen and contribute to your bronchial asthma signs.
Different monoclonal antibodies that focus on eosinophils and deal with eosinophilic asthma embody:
- Fasenra (benralizumab)
- Nucala (mepolizumab)
Selecting between a monoclonal antibody will depend upon a number of components, together with your age. Cinqair is just authorised to deal with adults, whereas Fasenra is authorised to deal with individuals 12 years and older. Nucala can be utilized in adults and kids 6 years and older.
The route of administration additionally varies. Cinqair requires an intravenous (IV) infusion, whereas Nucala and Fasenra are administered as a subcutaneous injection (below your pores and skin). After correct coaching, some individuals can administer Nucala or Fasenra at house, saving you the go to to your healthcare supplier’s workplace. All three merchandise are administered each 4 weeks initially. Nonetheless, after the primary three doses, Fasenra solely must be taken each eight weeks.
Lastly, value can also be a consideration. Your insurance coverage supplier might favor one product over one other. You and your healthcare supplier will work collectively to find out one of the best remedy possibility for you.
How Can I Keep Wholesome Whereas Taking Cinqair?
In case you’re struggling to get your bronchial asthma signs below management, your inhalers and even oral steroids is probably not sufficient. Your healthcare supplier might advocate beginning a biologic product, like Cinqair, to assist scale back bronchial asthma assaults and enhance your respiration.
It is necessary to do not forget that Cinqair is a upkeep remedy. It isn’t a rescue treatment and won’t deal with an energetic bronchial asthma assault. Speak together with your healthcare supplier about your bronchial asthma remedy routine and be sure you know which medicines to take if you happen to develop bother respiration.
Medical Disclaimer
Verywell Well being’s drug info is supposed for academic functions solely and isn’t supposed to switch medical recommendation, prognosis, or remedy from a healthcare supplier. Seek the advice of your healthcare supplier earlier than taking any new treatment(s). IBM Watson Micromedex gives a number of the drug content material, as indicated on the web page.
