The Altos government crew can be composed of Hal Barron, MD (incoming CEO), Rick Klausner, MD (Chief Scientist and Founder), Hans Bishop (President and Founder), and Ann Lee-Karlon, PhD (Chief Working Officer). Hal Barron is at present President of R&D and Chief Scientific Officer at GSK and can be part of Altos as CEO and Board co-chair efficient August 1, 2022. Klausner was former director of the Nationwide Most cancers Institute and entrepreneur, Bishop was former CEO of GRAIL and Juno Therapeutics, and Lee-Karlon was former Senior Vice President at Genentech.
Altos can be initially based mostly within the US within the San Francisco Bay Space and San Diego, and within the UK in Cambridge. The corporate may even have vital collaborations in Japan. Set inside these geographies, exercise can be organized throughout the Institutes of Science and the Institute of Drugs. The Altos Institutes of Science will pursue deep scientific questions and combine their findings into one collaborative analysis effort. The Altos Institute of Drugs will seize information generated about cell well being and programming to develop transformative medicines.
The three Altos Institutes of Science can be led by Juan Carlos Izpisua Belmonte, PhD, Wolf Reik, MD, and Peter Walter, PhD. Thore Graepel, PhD, will function world head of computational science, synthetic intelligence, and machine studying. Previous to becoming a member of Altos, Izpisua Belmonte was professor and chair on the Salk Institute, Reik was director of the Babraham Institute and is an honorary professor on the College of Cambridge, and Walter was professor on the College of California, San Francisco (UCSF) and investigator on the Howard Hughes Medical Institute. Graepel beforehand served as analysis lead at Google DeepMind and professor at College School London. Throughout the Institutes of Science, a unprecedented group of Principal Investigators (PIs) will collaboratively pursue the numerous features of cell well being and programming. A full itemizing of PIs is discovered at altoslabs.com.
The Altos Board of Administrators and advisors embrace Nobel Laureates and scientific leaders. The Board can be co-chaired by Rick Klausner, Hans Bishop, and Hal Barron (present director and incoming co-chair) and contains the next Board administrators: Frances Arnold, PhD (Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry on the California Institute of Expertise and Nobel Laureate), Hal Barron, MD (Chief Scientific Officer and President, R&D, of GSK), Jennifer Doudna (Li Ka Shing Chancellor’s Chair and Professor of Chemistry and Molecular and Cell Biology on the College of California, Berkeley, President of the Revolutionary Genomics Institute, and Nobel Laureate), Maria Leptin, PhD (President of the European Analysis Council), Robert Nelsen (Co-founder and Managing Director of ARCH Enterprise Companions), Rajiv Shah, MD (President of the Rockefeller Basis), and David Baltimore, PhD (President Emeritus and Choose Shirley Hufstedler Professor of Biology on the California Institute of Expertise and Nobel Laureate), as lead unbiased director. Shinya Yamanaka, MD, PhD (Director of the Heart for iPS Cell Analysis and Software at Kyoto College and Nobel Laureate), will function senior scientific advisor to Altos with out remuneration, overseeing analysis actions in Japan.
“I’m deeply honored to have been supplied this as soon as in a lifetime alternative to steer such a singular firm with a transformative mission to reverse illness,” mentioned Hal Barron. “It is clear from work by Shinya Yamanaka, and lots of others since his preliminary discoveries, that cells have the flexibility to rejuvenate, resetting their epigenetic clocks and erasing harm from a myriad of stressors. These insights, mixed with main advances in quite a lot of transformative applied sciences, impressed Altos to reimagine medical remedies the place reversing illness for sufferers of any age is feasible.”
Altos is designed to combine the very best options of academia and trade — from academia the liberty to pursue essentially the most difficult issues in biology, and from trade the give attention to a shared mission, capability to foster deep collaborations, and the fervour and dedication to rework science into medicines.
“Altos seeks to decipher the pathways of mobile rejuvenation programming to create a totally new method to medication, one based mostly on the rising ideas of mobile well being,” mentioned Rick Klausner. “Outstanding work over the previous couple of years starting to quantify mobile well being and the mechanisms behind that, coupled with the flexibility to successfully and safely reprogram cells and tissues through rejuvenation pathways, opens this new vista into the drugs of the longer term. Altos begins with lots of the main scientists who’re creating this new science. Collectively, we’re constructing an organization the place lots of the world’s finest scientists can collaborate internally and externally and develop their analysis with the velocity, mission, and focus of personal enterprise. Our success will rely upon a tradition of intense collaboration, enthusiasm, and openness.”
“Constructing an organization with extraordinary ambition requires extraordinary individuals,” mentioned Hans Bishop. “It should additionally require constructing an innovation tradition that brings out the very best in individuals from very numerous backgrounds. We intention to amplify the very best attributes of academia and firms with the purpose to speed up drawback fixing. I am excited to be becoming a member of a crew with such an inspiring mission and the interior ambition of constructing an organization the place all of us can say that we’re doing our easiest work.”
Frances Arnold, Board member and Nobel laureate, believes that “Altos presents a complete new analysis and growth mannequin focused to the oldest of human issues, slowing and even finally reversing the consequences of illness. This exceptional crew is poised to find secrets and techniques of mobile well being and remodel the best way we take into consideration illness. Now greater than ever is the time to restructure our method to well being by understanding, slowing, and even reversing the processes that result in sickness and loss of life.”
“As a geneticist and developmental biologist, I discover nice promise within the rising recognition that the metabolic management of cell well being contributes decisively to the flexibility of an organism to tolerate main systemic insults from congenital and infectious illness to emphasize and growing old,” mentioned Maria Leptin, Board member and ERC president. “As a dedicated believer in curiosity-driven analysis, I welcome a broad method to making an attempt to know the basic mobile ideas concerned in returning the confused organism to a wholesome equilibrium state.”
Shinya Yamanaka, senior scientific advisor and Nobel laureate, mentioned, “I’m delighted to be part of Altos and imagine it to be one of the vital and thrilling new world scientific endeavors. The potential of rejuvenation programming has solely not too long ago grow to be a scientific actuality and has the potential to allow us to method human illness in a completely new method. I’m glad that I’ll assist scientists in Japan to work on this thrilling discipline.”
“I’m honored to function the lead unbiased Director of the newly fashioned Altos Labs,” mentioned David Baltimore, Board member and Nobel laureate. “Altos will construct on the exceptional growing understanding of the alterations of cells as they take part within the myriad processes of the human physique over its lifespan. The purpose of Altos can be to reverse the ravages of illness and growing old that result in incapacity and loss of life, reinvigorating and lengthening the standard of life. Altos will present an unparalleled setting for collaborative discovery and has already attracted a most spectacular group of investigators to the daunting process of reversing sick well being and taking medication in a brand new course.”
About Altos Scientific Management
The Altos Bay Space Institute of Science can be led by Peter Walter, PhD, whose analysis has targeted on growing molecular understanding of how cells management the standard of their proteins and organelles throughout homeostasis and stress. Dr. Walter is the recipient of quite a few awards, together with the Shaw Prize, the Lasker Award for Primary Medical Analysis, the Vilcek Prize for Biomedical Science, and the Breakthrough Prize in Life Sciences. He’s a member of the Nationwide Academy of Sciences, American Academy of Arts and Sciences, the Nationwide Academy of Drugs, and the Nationwide Academy of Inventors. Previous to becoming a member of Altos, Dr. Walter was professor within the Division of Biochemistry/Biophysics on the College of California, San Francisco (UCSF) and an investigator on the Howard Hughes Medical Institute.
The Altos San Diego Institute of Science can be led by Juan Carlos Izpisua Belmonte, PhD. Dr. Izpisua Belmonte is a pioneer within the discipline of regenerative medication. He has developed quite a few methods to enhance well being, together with tissue and organ regeneration and mobile and organismal rejuvenation. He was the recipient of a Nationwide Science Basis Creativity Award, a Nationwide Institutes of Well being Director’s Pioneer Award, the William Clinton Presidential Award, the Pew Scholar Award, the Gold Medal of Castilla-La Mancha, and the Roger Guillemin Endowed Nobel Chair. Previous to Altos, Dr. Izpisua Belmonte was professor within the Gene Expression Laboratory and the Roger Guillemin chair on the Salk Institute in La Jolla, California.
The Altos Cambridge (UK) Institute of Science can be led by Wolf Reik, MD. Dr. Reik is a frontrunner in epigenetic reprogramming of mammalian cells, honorary professor of Epigenetics on the College of Cambridge, and served most not too long ago as director of the Babraham Institute in Cambridge. He’s the recipient of the Wellcome Prize in Physiology and is a member of the European Molecular Biology Organisation and the Academia Europaea, a Fellow of the Academy of Medical Sciences and of the Royal Society.
Altos may even help actions in Japan, guided by Shinya Yamanaka, MD, PhD, who will function Altos senior scientific advisor with out remuneration. Dr. Yamanaka is among the many world’s main authorities on stem cell science and is a recipient of the 2012 Nobel Prize in Physiology or Drugs for the invention of induced pluripotent stem cells. He at present serves because the director of the Heart for iPS Cell Analysis and Software (CiRA) at Kyoto College and a senior investigator on the Gladstone Institutes.
Throughout all features of Altos can be a dedication to computational science, machine studying, and synthetic intelligence with actions led by Thore Graepel, PhD. Graepel was most not too long ago analysis lead at Google DeepMind and chair of Machine Studying at College School London and is likely one of the foremost minds on the way to construct extra clever methods and brokers that study from expertise.
About Altos Labs
Altos Labs™ (Altos™) is a biotechnology firm targeted on mobile rejuvenation programming to revive cell well being and resilience, with the purpose of reversing illness to rework medication. The corporate contains a neighborhood of main scientists, clinicians, and leaders from each academia and trade working collectively in the direction of this frequent mission.
Altos has operations within the San Francisco Bay Space and San Diego, and in Cambridge, UK, with vital collaborations in Japan.
Go to www.altoslabs.com to study extra about Altos, together with a full checklist of our senior scientists and leaders.
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