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Thorac Most cancers. 2021 Nov 5. doi: 10.1111/1759-7714.14208. On-line forward of print.
ABSTRACT
BACKGROUND: Chemoresistance is a serious barrier limiting the therapeutic efficacy of late stage non-small cell lung most cancers (NSCLC). On this examine, we sought to make use of two-dimensional titanium carbide (2D Ti2 C) to reverse cisplatin resistance in NSCLC.
METHODS: We first achieved favorable properties as a possible anti-tumor agent. We then in contrast cell viability and cisplatin uptake in chemoresistant NSCLC cells earlier than and after using 2D Ti2 C. Afterwards, we explored the results of 2D Ti2 C on intracellular antioxidant reserves, adopted by evaluating the next adjustments within the expression of core drug resistance genes. Lastly, we confirmed the tumor inhibitory impact and bio-safety of 2D Ti2 C in a drug-resistant lung most cancers mannequin in nude mice.
RESULTS: As a result of properties of skinny layer, giant particular floor space, and ample reactive teams on the floor, 2D Ti2 C can deplete the antioxidant reserve programs such because the glutathione redox buffer system, γ-glutamylcysteine synthetase (γ-GCS), glutathione peroxidase (GPx), glutathione-S-transferase-Pi (GST-π), and metallothionein (MT), thereby rising the intracellular accumulation of cisplatin and reducing the expression of drug resistance genes.
CONCLUSIONS: 2D Ti2 C can reverse NSCLC chemoresistance each in vitro and in vivo, suggesting that it might probably change into a novel and efficient means to deal with chemoresistant NSCLC within the clinic.
PMID:34741403 | DOI:10.1111/1759-7714.14208
