BOSTON–(BUSINESS WIRE)–PureTech Health plc (Nasdaq: PRTC, LSE: PRTC) (“PureTech” or the “Firm”), a clinical-stage biotherapeutics firm, famous at the moment that its Based Entity, Gelesis, Inc. (“Gelesis”) introduced at the moment a publication in Nature’s Scientific Reports describing the genesis of the underlying expertise and engineering course of for Gelesis’ non-systemic superabsorbent hydrogels. These new supplies had been designed to duplicate compositional and mechanical properties of uncooked greens, and the paper describes their therapeutic method for weight administration in addition to attainable future options for different gut-related situations.
Vegetable consumption is a basic a part of many dietary interventions. Greens occupy quantity within the abdomen, decreasing the caloric density of a meal, and their options are recognized to boost satiety. But within the therapy of weight problems and different associated situations like diabetes or gut-related ailments, dietary and behavioral modifications are sometimes tough to implement and keep. Gelesis thus engineered a novel, cellulose-based superabsorbent hydrogel platform designed to imitate lots of the properties of uncooked greens. Whereas not a substitute for greens because it doesn’t present any energy or micronutrients, the superabsorbent hydrogels had been designed that can assist you eat much less so you possibly can drop some weight.
The analysis examined the composition and mechanical properties of the novel superabsorbent hydrogels in comparison with these of uncooked greens and useful fibers. The superabsorbent hydrogels demonstrated elasticity at orders of magnitude above the examined useful fibers and, as meant, much like the examined uncooked greens. Notably, these hydrogels with elasticity ranges much like uncooked greens confirmed advantages in preserving and regulating intestine tissue in an ex-vivo organ tradition mannequin.
“To my data, that is the primary and solely superabsorbent hydrogel expertise that’s made solely from food-derived constructing blocks. This was fairly an engineering feat within the biomaterials world,” stated Dr. Robert Langer, certainly one of solely 12 Institute Professors on the Massachusetts Institute of Expertise and essentially the most cited engineer in historical past. Dr Langer can be a co-founder of dozens of biotechnology firms together with PureTech Well being and Moderna. “It’s thrilling to see how this terrific work has already led to merchandise that would probably enhance the lives of tens of millions of individuals,” added Dr. Langer.
The complete textual content of the announcement from Gelesis is as follows:
Nature’s Scientific Reviews Options Gelesis’ Novel and Foundational Biomimetic Platform for Treating Weight problems and Situations Associated to Weight-reduction plan-Induced Intestine Injury
New paper describes the primary superabsorbent hydrogel expertise made out of naturally derived constructing blocks designed to handle weight problems and intestine associated situations by emulating compositional and mechanical properties of uncooked greens
The newly revealed information confirmed that particular mechanical properties (elastic part/firmness) of Gelesis hydrogels had been helpful in defending intestine tissue from toxin harm in an ex-vivo mannequin
First product primarily based on this platform, Plenity®, is now FDA cleared and out there by prescription to assist in weight administration
Gelesis’ pipeline contains a number of different therapeutic product candidates in superior medical growth to probably deal with a spread of indications together with diet-induced intestine harm
BOSTON, November 1, 2021 – Gelesis, a consumer-focused biotherapeutics firm and the maker of Plenity®, introduced at the moment a publication in Nature’s Scientific Reviews describing the genesis of the underlying expertise and engineering course of for Gelesis’ non-systemic superabsorbent hydrogels. These new supplies had been designed to duplicate compositional and mechanical properties of uncooked greens, and the paper describes their therapeutic method for weight administration in addition to attainable future options for different gut-related situations.
“To my data, that is the primary and solely superabsorbent hydrogel expertise that’s made solely from food-derived constructing blocks. This was fairly an engineering feat within the biomaterials world,” stated Dr. Robert Langer, certainly one of solely 12 Institute Professors on the Massachusetts Institute of Expertise and essentially the most cited engineer in historical past. Dr Langer can be a co-founder of dozens of biotechnology firms together with PureTech Well being (co-founder of Gelesis) and Moderna. “It’s thrilling to see how this terrific work has already led to merchandise that would probably enhance the lives of tens of millions of individuals,” added Dr. Langer.
Vegetable consumption is a basic a part of many dietary interventions. Greens occupy quantity within the abdomen, decreasing the caloric density of a meal, and their options are recognized to boost satiety. But within the therapy of weight problems and different associated situations like diabetes or gut-related ailments, dietary and behavioral modifications are sometimes tough to implement and keep. Gelesis thus engineered a novel, cellulose-based superabsorbent hydrogel platform designed to imitate lots of the properties of uncooked greens. Whereas not a substitute for greens because it doesn’t present any energy or micronutrients, the superabsorbent hydrogels had been designed that can assist you eat much less so you possibly can drop some weight.
“We needed to create a big quantity that will combine with meals within the abdomen, with out including energy, like consuming a giant salad.” stated Dr. Alessandro Sannino, inventor and lead scientist for Gelesis and Professor of Polymer Science and Expertise, Deputy Rector and the Director of the Bioslabs on the College of Salento. “Clearly a brand new superabsorbent materials was wanted to permit for the administration in a handy trend, utilizing solely a small variety of capsules. We additionally needed to emulate the properties of a considerable amount of ingested uncooked greens because the objective was to focus on what we imagine is among the root causes of the weight problems pandemic, which is the trendy Western Weight-reduction plan, and the way it impacts us.”
The analysis examined the composition and mechanical properties of the novel superabsorbent hydrogels in comparison with these of uncooked greens and useful fibers. The superabsorbent hydrogels demonstrated elasticity at orders of magnitude above the examined useful fibers and, as meant, much like the examined uncooked greens. Notably, these hydrogels with elasticity ranges much like uncooked greens confirmed advantages in preserving and regulating intestine tissue in an ex-vivo organ tradition mannequin. The paper might be learn here.
“We had been shocked to learn the way essential the elasticity stage of the examined hydrogels was on the integrity of the intestine tissue, in our ex-vivo mannequin. We used to consider dietary fibers when it comes to their composition and solubility, and we didn’t recognize the significance of their mechanical properties. We realized that uncooked greens are precisely within the candy spot of the intestine tissue in our mannequin,” stated Dr. Maria Rescigno, Deputy Rector and Group Chief Mucosal Immunology and Microbiota Unit – Humanitas College. “Our information may open a brand new route of analysis on tissue materials mechanical interactions, and the extremely tunable and biocompatible Gelesis hydrogels are glorious candidates to discover new mechanotransduction primarily based therapeutic approaches.”
Gelesis’ first business product, Plenity, accommodates certainly one of these superabsorbent hydrogels. Plenity is designed to assist folks really feel happy with smaller parts to allow them to handle their weight. It’s FDA-cleared to assist in weight administration in adults with extra weight or weight problems, Physique Mass Index (BMI) of 25 to 40 kg/m², when used together with food regimen and train. It’s taken orally as three capsules with 16 oz. of water twice a day, 20 minutes earlier than lunch and dinner. Gelesis has additionally acquired regulatory approval to market Plenity within the European Financial Space. Additional indications, associated to metabolic ailments and intestine well being, are being explored, using a number of hydrogel candidates from this platform.
About Gelesis
Gelesis is a consumer-centered biotherapeutics firm advancing a novel class of therapies for weight administration and intestine associated power ailments. Our non-systemic superabsorbent hydrogels are the primary and solely made totally from naturally derived constructing blocks, and they’re impressed by the composition (i.e., water & cellulose) and mechanical properties (e.g., elasticity or firmness) of uncooked greens. Designed for comfort, they’re administered in capsules to create a a lot bigger quantity of small, non-aggregating hydrogel items that blend with meals within the abdomen, and act regionally within the digestive system. Our portfolio contains Plenity®, an FDA-cleared product to assist in weight administration, in addition to potential therapies in growth for Sort 2 Diabetes, Non-alcoholic Fatty Liver Illness (NAFLD)/Non-alcoholic Steatohepatitis (NASH), and Practical Constipation. In July 2021, we introduced with Capstar Particular Function Acquisition Corp. (NYSE: CPSR) that we now have entered right into a definitive enterprise mixture settlement. Upon completion of the transaction, the mixed firm’s securities are anticipated to be traded on the New York Inventory Trade underneath the image “GLS.”
For extra data, go to gelesis.com, or join with us on Twitter @GelesisInc.
About Plenity
Plenity is designed to assist folks really feel happy with smaller parts to allow them to handle their weight. It’s FDA-cleared to assist in weight administration in adults with extra weight or weight problems, Physique Mass Index (BMI) of 25 to 40 kg/m², when used together with food regimen and train. It’s taken orally as three capsules with 16 oz. of water twice a day, 20 minutes earlier than lunch and dinner. If a dose is missed it may be taken with the meal or instantly following the meal. Plenity is just not a drug, non-systemic, and never behavior forming. It makes use of a novel biomimetic method impressed by the composition and mechanical properties of greens.
Necessary Security Details about Plenity
- Sufferers who’re pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide shouldn’t take Plenity.
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To keep away from influence on the absorption of medicines:
- For all medicines that ought to be taken with meals, take them after beginning a meal.
- For all medicines that ought to be taken with out meals (on an empty abdomen), proceed taking up an empty abdomen or as really helpful by your doctor.
- The general incidence of unwanted side effects with Plenity was no completely different than placebo. The most typical unwanted side effects had been diarrhea, distended stomach, rare bowel actions, and flatulence.
- Contact a physician straight away if issues happen. When you’ve got a extreme allergic response, extreme abdomen ache, or extreme diarrhea, cease utilizing Plenity till you possibly can converse to your physician.
Rx Solely. For the protected and correct use of Plenity or extra data, speak to a healthcare skilled, learn the Patient Instructions for Use, or name 1-844-PLENITY.
Extra Info and The place to Discover It
In July, Gelesis entered right into a enterprise mixture settlement with Capstar Particular Function Acquisition Corp. (NYSE: CPSR) (“Capstar”), a particular objective acquisition firm.
Capstar has filed a Registration Assertion on Type S-4 with the SEC, which features a proxy assertion/prospectus, that shall be each the proxy assertion to be distributed to Capstar shareholders in reference to its solicitation of proxies for the vote by Capstar shareholders with respect to the proposed enterprise mixture and different issues as could also be described within the Registration Assertion, in addition to the prospectus referring to the issuance of sure securities to be issued within the proposed enterprise mixture. After the Registration Assertion is asserted efficient, the proxy assertion/prospectus and different related paperwork shall be despatched to Capstar and Gelesis shareholders. Capstar additionally will file different paperwork concerning the proposed transaction with the SEC. This press launch doesn’t comprise all the data that ought to be thought-about in regards to the proposed enterprise mixture and isn’t meant to kind the premise of any funding resolution or some other resolution in respect of the proposed enterprise mixture. Earlier than making any voting resolution, Capstar’s shareholders and different individuals are suggested to learn, when out there, the preliminary proxy assertion/prospectus included within the Registration Assertion, the amendments thereto and the definitive proxy assertion/prospectus and all different related paperwork filed or that shall be filed with the SEC in reference to the proposed transaction as they turn out to be out there as a result of they’ll comprise essential details about Gelesis, Capstar and the proposed transaction.
When out there, the definitive proxy assertion/prospectus and different related supplies for the proposed enterprise mixture shall be mailed to shareholders of Capstar as of the document date established for voting on the proposed enterprise mixture. Traders and safety holders may even be capable to acquire free copies of the Registration Assertion, the proxy assertion/prospectus and all different related paperwork filed or that shall be filed with the SEC by Capstar, with out cost, as soon as out there, by the web site maintained by the SEC at www.sec.gov. The paperwork filed by Capstar with the SEC additionally could also be obtained freed from cost at Capstar’s web site at www.capstarspac.com, or by written request to: Capstar Particular Function Acquisition Corp., 405 West 14th Avenue, Austin, TX 78701, Consideration: R. Steven Hicks, Chief Government Officer, (512) 340-7800.
Individuals within the Solicitation
Capstar and its administrators and government officers could also be deemed members within the solicitation of proxies from Capstar’s shareholders with respect to the proposed enterprise mixture. The names of these administrators and government officers and an outline of their pursuits in Capstar is contained in Capstar’s ultimate prospectus dated July 6, 2020 referring to its preliminary public providing and in subsequent filings with the SEC, which can be found freed from cost on the SEC’s site at www.sec.gov. To the extent such holdings of Capstar’s securities could have modified since that point, such adjustments have been or shall be mirrored on Statements of Modifications in Useful Possession on Type 4 filed with the SEC. Extra data concerning the pursuits of such members shall be contained within the proxy assertion/prospectus for the proposed enterprise mixture when out there.
Gelesis and its administrators and government officers may additionally be deemed to be members within the solicitation of proxies from the shareholders of Capstar in reference to the proposed enterprise mixture. A listing of the names of such administrators and government officers and data concerning their pursuits within the proposed enterprise mixture shall be included within the proxy assertion/prospectus for the proposed enterprise mixture when out there.
Ahead-Wanting Statements
Sure statements, estimates, targets and projections on this press launch could represent “forward-looking statements” inside the that means of the federal securities legal guidelines. The phrases “anticipate,” “imagine,” “proceed,” “may,” “estimate,” “count on,” “intend,” “could,” “may,” “plan,” “attainable,” “potential,” “predict,” “undertaking,” “ought to,” “attempt,” “would” and comparable expressions could determine forward-looking statements, however the absence of those phrases doesn’t imply that assertion is just not ahead trying. Ahead-looking statements are predictions, projections and different statements about future occasions which can be primarily based on present expectations and assumptions and, because of this, are topic to dangers and uncertainties. Ahead-looking statements embody, however usually are not restricted to, statements concerning the satisfaction of closing situations to the proposed enterprise mixture and the anticipated timing of the completion of the proposed enterprise mixture, the advantages of the proposed enterprise mixture, the aggressive setting through which Gelesis operates, the anticipated future working and monetary efficiency and market alternatives of Gelesis and statements concerning Gelesis’ and Capstar’s expectations, hopes, beliefs, intentions or methods concerning the longer term. As well as, any statements that confer with projections, forecasts, or different characterizations of future occasions or circumstances, together with any underlying assumptions, are forward-looking statements. Ahead-looking statements converse solely as of the date they’re made. Readers are cautioned to not put undue reliance on forward-looking statements, and Gelesis and Capstar assume no obligation and don’t intend to replace or revise these forward-looking statements, whether or not on account of new data, future occasions, or in any other case. Gelesis and Capstar give no assurance that any expectations set forth on this press launch shall be achieved. Numerous elements may trigger precise future outcomes, efficiency or occasions to vary materially from these described herein. A number of the elements which will influence future outcomes and efficiency could embody, with out limitation: (i) the dimensions, demand and progress potential of the markets for Plenity®, Gelesis’ different product candidates and its potential to serve these markets; (ii) the diploma of market acceptance and adoption of Gelesis’ merchandise; (iii) Gelesis’ potential to develop revolutionary merchandise and compete with different firms engaged within the weight reduction trade; (iv) Gelesis’ potential to finish efficiently the complete business launch of Plenity® and its progress plans, together with new attainable indications and the medical information from ongoing and future research about liver and different ailments; (v) the lack of the events to efficiently or well timed consummate the proposed enterprise mixture, together with the danger that any required regulatory approvals usually are not obtained, are delayed or are topic to unanticipated situations that would adversely have an effect on the mixed firm or the anticipated advantages of the enterprise mixture or that the approval of the shareholders of Capstar is just not obtained; (vi) failure to appreciate the anticipated advantages of the enterprise mixture, together with on account of a delay or problem in integrating the companies of Capstar and Gelesis; (vii) the quantity of redemption requests made by Capstar shareholders; (viii) the power of Capstar or the mixed firm to situation fairness or equity-linked securities or acquire debt financing in reference to the proposed enterprise mixture or sooner or later; (ix) the end result of any authorized proceedings that could be instituted in opposition to Capstar, Gelesis, the mixed firm or others following the announcement of the proposed enterprise mixture and any definitive agreements with respect thereto; (x) the power to satisfy inventory alternate itemizing requirements at or following the consummation of the proposed enterprise mixture; (xi) the danger that the proposed enterprise mixture disrupts present plans and operations of Gelesis on account of the announcement and consummation of the proposed enterprise mixture, and on account of the post-transaction firm being a publicly listed issuer; (xii) the regulatory pathway for Gelesis’ merchandise and product candidates and responses from regulators, together with the FDA and comparable regulators exterior of the US, (xiii) the power of the mixed firm to develop and handle progress profitably, keep relationships with clients and suppliers and retain Gelesis’ administration and key staff; (xiv) prices associated to the proposed enterprise mixture, together with prices related to the post-transaction firm being a publicly listed issuer; (xv) adjustments in relevant legal guidelines or laws; (xvi) the likelihood that Gelesis or the mixed firm could also be adversely affected by different financial, enterprise, regulatory and/or aggressive elements; (xvii) Gelesis’ estimates of bills and profitability; (xviii) ongoing regulatory necessities, (xix) any competing merchandise or applied sciences which will emerge, (xx) the volatility of the telehealth market basically, or inadequate affected person demand; (xxi) the power of Gelesis to defend its mental property and fulfill regulatory necessities; (xxii) the influence of the COVID-19 pandemic on Gelesis’ enterprise; (xxiii) the restricted working historical past of Gelesis; and (xxiv) these elements mentioned in Capstar’s ultimate prospectus dated July 6, 2020 and Annual Report on Type 10-Okay for the fiscal yr ended December 31, 2020 and the Registration Assertion, in every case, underneath the heading “Threat Components”, and different paperwork of Capstar filed, or to be filed, with the SEC, together with the proxy assertion/prospectus included within the Registration Assertion filed by Capstar with the SEC. These filings handle different essential dangers and uncertainties that would trigger precise outcomes and occasions to vary materially from these contained within the forward-looking statements.
Non-Solicitation
This press launch is just not a proxy assertion or solicitation of a proxy, consent or authorization with respect to any securities or in respect of the proposed enterprise mixture and shall not represent a suggestion to promote or a solicitation of a suggestion to purchase the securities of Capstar, Gelesis or the mixed firm, nor shall there be any sale of any such securities in any state or jurisdiction through which such supply, solicitation, or sale can be illegal previous to registration or qualification underneath the securities legal guidelines of such state or jurisdiction. No supply of securities shall be made besides via a prospectus assembly the necessities of the Securities Act of 1933, as amended.
About PureTech Well being
PureTech is a clinical-stage biotherapeutics firm devoted to discovering, growing and commercializing extremely differentiated medicines for devastating ailments, together with inflammatory, fibrotic and immunological situations, intractable cancers, lymphatic and gastrointestinal ailments and neurological and neuropsychological problems, amongst others. The Firm has created a broad and deep pipeline by the experience of its skilled analysis and growth workforce and its intensive community of scientists, clinicians and trade leaders. This pipeline, which is being superior each internally and thru PureTech’s Based Entities, is comprised of 25 therapeutics and therapeutic candidates, together with two which have acquired each U.S. FDA clearance and European advertising and marketing authorization, as of the date of PureTech’s most just lately filed Half 12 months Report and corresponding Type 6-Okay. The entire underlying applications and platforms that resulted on this pipeline of therapeutic candidates had been initially recognized or found after which superior by the PureTech workforce by key validation factors primarily based on the Firm’s distinctive insights into the biology of the mind, immune and intestine, or BIG, programs and the interface between these programs, known as the BIG Axis.
For extra data, go to www.puretechhealth.com or join with us on Twitter @puretechh.
Cautionary Observe Relating to Ahead-Wanting Statements
This press launch accommodates forward-looking statements inside the that means of the Non-public Securities Litigation Reform Act of 1995. All statements contained on this press launch that don’t relate to issues of historic truth ought to be thought-about forward-looking statements, together with with out limitation statements that relate to the enterprise mixture settlement between Gelesis and Capstar Particular Function Acquisition Corp. (NYSE: CPSR) or issues associated thereto, Gelesis’ future prospects, growth plans, and methods. The forward-looking statements are primarily based on present expectations and are topic to recognized and unknown dangers, uncertainties and different essential elements that would trigger precise outcomes, efficiency and achievements to vary materially from present expectations, together with, however not restricted to, these dangers, uncertainties and different essential elements described underneath the caption “Threat Components” in our Annual Report on Type 20-F for the yr ended December 31, 2020 filed with the SEC and in our different regulatory filings. These forward-looking statements are primarily based on assumptions concerning the current and future enterprise methods of the Firm and the setting through which it’s going to function sooner or later. Every forward-looking assertion speaks solely as on the date of this press launch. Besides as required by legislation and regulatory necessities, we disclaim any obligation to replace or revise these forward-looking statements, whether or not on account of new data, future occasions or in any other case.